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Table 1 summarizes the noticed DLTs by cohort. Somnolence, which solved in all but 1 individual, was the sole DLT for MLN8054 given without methylphenidate or modafinil. The onset of somnolence and its severity generally ended up correlated with dose and Cmax. For the reason that somnolence was regarded as linked to Cmax, the dosing program was imp
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